The major road repair blitz was due to launch in March, but was put on hold with resources focused on the town's response to the Coronavirus pandemic.
With lockdown measures now starting to ease, the ambitious programme - spearheaded by Middlesbrough Deputy Mayor Councillor Antony High - is now set to resume.
Over 20 weeks, every ward in Middlesbrough will be targeted in succession, with work set to start on Monday, June 29.
Wards will be tackled in alphabetical order following detailed inspections to identify all potholes requiring repair.
The work will be carried out by the Council's Highways Infrastructure Team, with extra resources on hand as required to meet the 20-week deadline and pick up on any issues and defects following the initial repair.
Deputy Mayor Antony High said: "Potholes cause disruption and misery to road users, and they shouldn't have to put up with them.
"They're costly and dangerous, so it's great to be getting this town-wide programme under way, and sort out our roads once and for all.
"This approach is the first of its kind for Middlesbrough and I am delighted to have spearheaded this project to help improve our town."
Middlesbrough Mayor Andy Preston said: "We know people are sick and tired of potholes, so I'm sure the public will be right behind such a great initiative.
"We'll be looking to ensure that this approach continues well beyond the initial 20-week programme."
For the latest local updates and information, visit www.middlesbrough.gov.uk/covid19
For information on local help and support, visit Help Boro at www.middlesbrough.gov.uk/helpboro or call Middlesbrough Council's support line 01642 729777
The latest advice from Government and Public Health England can be found at https://www.gov.uk/coronavirus
